Central administration of palmitoylethanolamide cuts down hyperalgesia in mice through inhibition of NF??B nuclear signalling in dorsal root ganglia. Eur J Pharmacol1996). Oral PEA also minimized paw oedema induced by carrageenan, dextran and formalin, suggesting the compound instantly down?modulates mast cell activation in vivoNone of the RCTs tal

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